Education:
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2008-present |
Professor of Neurochemistry in Pharmaceutical Sciences |
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2008-present |
Professor, Department of Anatomy and Neurobiology, Northeastern Ohio Universities College of Medicine |
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2003-2008 |
Professor, Department of Anatomy, Northeastern Ohio Universities College of Medicine |
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1997-1998 |
DAAD Visiting Scholar Fellow: Max Planck Institute of Psychiatry, Munich, Germany |
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1994-2002 |
Associate Professor, Department of Anatomy, Northeastern Ohio Universities College of Medicine |
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1990-1994 |
Assistant Professor, Department of Anatomy, Northeastern Ohio Universities College of Medicine |
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1983-1990 |
Research Associate/Visiting Lecturer, Department of Physiology and Biophysics, University of Illinois |
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1980-1982 |
Research Associate, Department of Psychology and Biophysics, University of Illinois |
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1980 |
Research Associate, Department of Psychology, University of Illinois |
| 1978-1979 | NIH Postdoctoral Fellow, Reproductive Physiology Training Program, University of Illinois |
| 1978 | Research Assistant, Department of Edology, Ethology and Evolution, University of Illinois |
| 1974-1978 | Teaching Assistant, Illinois Institute of Technology |
| 1971-1973 | Mental Health Coordinator, Chicago-Read Mental Health Center |
Research Interests:
The major research of our laboratory involves an examination of age-related and neurotoxin-induced changes of the nigrostriatal dopaminergic system and how these neurodegenerative conditions are modulated by gonadal steroid hormones to result in the sex differences observed in such neurodegenerative disorders like Parkinson’s disease. In addition, we have also been using the psychostimulant, methamphetamine, as a means to study sex differences in dopaminergic function as related to neurotoxicity and addiction.
Selected Chapter/Review Publications:
- Dluzen, D. E. Unconventional effects of estrogen uncovered. Trends in Pharmacological Sciences 26:485, 2005.
- Liu, B. and Dluzen, D. E. Estrogen and Nigrostriatal Dopaminergic Neurodegeneration: Implications for Parkinson’s Disease. Clinical and Experimental Pharmacology and Physiology 34: 555, 2007.
- Dluzen, D. E. and Liu, B. Gender differences in methamphetamine use and responses: A Review. Gender Medicine, 5:24, 2008.
- Dluzen, D. E. and McDermott, J. L. Sex differences in dopamine- and vesicular monoamine-transporter functions: implications for methamphetamine use and toxicity. Annals of the New York Academy of Sciences, 2008 – In Press.
- Bourque, M., Dluzen, D. E. and Di Paolo, T. Neuroprotective actions of sex steroids in Parkinson’s disease. Frontiers in Neuroendocrinology 30:142, 2009.
Recent Manuscript Publications:
- Li, H., Liu, B., Dluzen, D. E. and Jin, Y. Protective effects of ginsenoside Rg2 against glutamate-induced neurotoxicity in PC12 cells. Journal of Ethnopharmacology, 111:458, 2007.
- Ji, J., McDermott, J. L. and Dluzen, D. E. Sex differences in potassium-evoked striatal dopamine output from superfused striatal tissue fragments of reserpine-treated CD-1 mice. Journal of Neuroendocrinology, 19: 725, 2007.
- Bourque, M., Liu, B., Dluzen, D. E. and Di Paolo, T. Tamoxifen protects male mice nigrostriatal dopamine against methamphetamine-induced toxicity. Biochemical Pharmacology, 74: 1413, 2007.
- McDermott, J. L. and Dluzen, D. E. Aging and sex differences in striatal dopaminergic function. Neuroscience, 149: 401, 2007.
- Ji, J. and Dluzen, D. E. Sex differences in striatal dopamine and DOPAC within heterozygous mutant dopamine transporter knock out mice. Journal of Neural Transmission, 115: 809, 2008.
- Dluzen, D. E., Bhatt, S. and McDermott, J. L. Differences in reserpine-evoked striatal dopamine output between female and male mice: Implications for sex differences in vesicular monoamine transporter 2 function. Neuroscience, 154; 1488, 2008.
- Ji, J., Bourque, M., Di Paolo, T. and Dluzen, D. E. Genetic alteration in the dopamine transporter differentially affects male and female nigrostriatal transporter systems. Biochemical Pharmacology, In Press, 2009.
