Corneal Development and Wound Healing

Kathleen J. Doane, Ph.D.

Assistant Professor
Department of Anatomy

Northeastern Ohio Universities
College of Medicine
4209 St. Rt. 44, P.O. Box 95
Rootstown, Ohio 44272-0095
Phone: (330) 325-6304
Fax: (330) 325-5913
Email: kd@neoucom.edu
Community of Science Expertise

Education:

1988	Ph.D.	Cell & Developmental Biology, Rutgers, The State University of New Jersey and UMDNJ, Piscataway, NJ
1981	M.S.	Zoology, Rutgers, The State University of New Jersey, New Brunswick, NJ
1977	B.A.	Biology, Grinnell College, Grinnell, Iowa

Professional Experience:

1994-present	Assistant Professor, Department of Anatomy, Northeastern Ohio Universities College of Medicine, Rootstown, OH
1992-1994	Research Fellow, Department of Anatomy and Cellular Biology, Tufts University School of Medicine, Boston, MA
1992	Instructor, Department of Pathology, Robert Wood Johnson Medical School, Piscataway, NJ
1988-1992	Post-doctoral Fellow, Department of Pathology, Robert Wood Johnson Medical School, Piscataway, NJ

Graduate Faculty Status:

Cell and Molecular Program/KSU

Research Interests:

My laboratory is interested in the role of cell-extracellular matrix interactions during corneal development and wound healing. For proper optical function, cells within the corneal stroma must synthesize and deposit a precisely organized array of collagen fibrils and other matrix components such that the cornea is transparent. We are examining the role of integrins, integral membrane proteoglycans and other matrix receptors in the process of cellular migration into the stroma, differentiation of these cells, and maintenance of mature corneal matrix architecture. We also investigate the role of matrix-receptor interactions and inflammatory cells, specifically macrophages, during healing of corneal wounds.

Selected Publications:

Doane, K. J. and D. E. Birk. Differences in integrin expression during avian corneal stromal development. Invest. Ophthal. Vis. Sci. 35:2834-2842 (1994).
Doane, K. J., W-H. Ting, J. S. McLaughlin and D. E. Birk. Spatial and temporal variations in extracellular matrix of periocular and corneal regions during corneal stromal development. Exp. Eye Res. 62:271-283 (1996).
Doane, K. J., S. Howell and D. E. Birk. Identification and functional characterization of two type VI collagen receptors, alpha-3, beta-1 and NG2, during avian corneal stromal development. Invest. Ophthal. Vis. Sci. 39:263-275 (1998).
Singh, B., K. J. Doane and G. D. Niehaus. Ultrastructural and cytochemical evaluation of sepsis-induced changes in the rat pulmonary intravascular mononuclear phagocytes. J. Anat. 192:13-23 (1998).
Howell, S. J. and K. J. Doane. Type VI collagen increases proliferation and prevents anti-beta-1 integrin induced-apoptosis. Exp. Cell Res., 241:230-241 (1998).