Chondrocyte Biology, Cartilage Disease, OsteoarthritisWalter E. Horton, Jr., Ph.D.Professor, Department of Anatomy
|
|
Northeastern Ohio Universities |  |
Funding Sources:
Arthritis Foundation, Northeastern Ohio Chapter
Musculoskeletal Transplant Foundation
National Institutes of Health
Education:
Musculoskeletal Transplant Foundation
National Institutes of Health
Education:
| 1984 | Ph.D. | Anatomy/Cell Biology, University of Cincinnati |
| 1979 | B.S. | Zoology, Kent State University |
Professional Experience:
|
2004-Present |
Professor, Department of Anatomy, Northeastern Ohio Universities College of Medicine |
|
1998-2004 | Associate Professor, Department of Anatomy, Northeastern Ohio Universities College of Medicine, Rootstown, Ohio |
| 1994-1998 | Senior Investigator (Tenure-Track), Laboratory of Biological Chemistry, Gerontology Research Center, NIA, NIH, Baltimore, MD |
| 1991-1994 | Senior Staff Fellow, Laboratory of Biological Chemistry, Gerontology Research Center, NIA, NIH, Baltimore, MD |
| 1989-1991 | Guest Researcher, Laboratory of Biological Chemistry, Gerontology Research Center, NIA, NIH, Baltimore, MD |
| 1986-1989 | Senior Biologist, Lilly Research Laboratories, Eli Lilly & Company, Indianapolis, IN |
| 1984-1987 | NRSA Fellow, NIDR, NIH, Bethesda, MD |
| 1982-1984 | Graduate Assistant, University of North Carolina |
| 1979-1982 | Graduate Assistant, University of Cincinnati |
Research Interests:
Regulation of chondrocyte gene expression, Apoptosis, Cartilage tissue engineering.
Selected Publications:
Adams, C.S., and W.E. Horton Jr. Chondrocyte apoptosis increases with age in the articular cartilage of adult animals. Anat Rec., 250: 418-425, 1998.
Bradham, D.E., and W.E. Horton Jr. In vivo cartilage formation from growth factor modulated articular chondrocytes. Clinical Orthopaedics and Related Research 352: 239-249, 1998
Feng, L., P. Precht, R. Balakir, and W.E. Horton Jr. Decreased Bcl-2 expression is associated with articuclar chondrocyte apoptosis induced by serum withdrawal and retinoic acid. J. Cellular Biochemistry. 71: 302-309, 1998
Lixin, F., Balakir, R., Precht, P., Horton Jr., W.E.: Bcl-2 Regulates Chondrocyte Morphology & Aggrecan Gene Expression Independent of Caspase Activation and Full Apoptosis. J. Cell. Biochem. 74: 576-586, 1999
Murray, D., Precht, P., Balakir, R., and Horton Jr., W.E.: The Transcription Factor delta EF1 Binds to a Sequence in the 5’Flanking Region of the Col2a1 Gene and Can Repress Promoter Activity in Transfected Chondrocytes. J. Biol. Chem. 275: 3610-3618, 2000
Potter, K., Butler, J.J., Horton Jr., W.E., and Spencer, R.G.S.: Response of engineered cartilage tissue to biochemical agents as studied by proton magnetic resonance microscopy. Arthritis & Rheum. 43: 1580-1590, 2000
Adams, C.S., and Horton Jr., W.E.: Apoptosis and Bone Disease. In Mattson, M.P., Estus, S., and Rangnekar, V. (Eds): Programmed Cell Death Volume II. Elsevier Science B.V. 2001, pp. 271-313.
Lucchinetti, E., Adams, C. S., Horton Jr, W.E .and Torzilli, P.A.: Cartilage viability afterrepetitive loading: a preliminary report. Osteoarthritis and Cartilage 10: 71-81, 2002
Kinkel M. and Horton Jr., W.E.: Coordinate down-regulation of cartilage matrix gene expression in Bcl-2 deficient chondrocytes is associated with decreased sox-9 expression and decreased mRNA stability. J. Cell Biochem. 88: 941-953, 2003
Chen, C., Torzilli, P., Spencer, R.G.S., Fishbein, K., and Horton Jr., W.E.: Magnetic Resonance Microscopy of Bioreactor-Derived Hyaline Cartilage Correlated with Biochemical and Biomechanical Properties. Arthritis and Rheumatism. 48: 1047-1056, 2003.
Kinkel, M., Yagi, R, and Horton Jr., W.E.: Age-Related Expression Patterns of Bag-1 and Bcl-2 in Growth Plate and Articular Chondrocytes. Anatomical Records Anat Rec. 279A(2):720-728 2004
Yagi, R., Laverty, D., Weiner, S., Horton Jr., W.E. Intrajoint comparisons of gene expression patterns in human osteoarthritis suggests a change in chondrocyte phenotype Journal of Orthopaedic Research. 23: 1128-1138. 2005.
Horton Jr., WE, Yagi R., Laverty D., Weiner S. Overview of studies comparing human normal cartilage with minimal and advanced osteoarthritic cartilage. Clincial and Experimental Rheumatology, Jan-Feb;23(1):103-12 2005
Adamczyk, MJ. Weiner DS, Nugent A, McBurney D, and Horton Jr. WE: Increased chondrocyte apoptosis in growth plates from children with slipped capital femoral epiphysis. J. of Pediatric Orthopaedics. July/August;25(4):440-444 2005
Kim M, Bi X, Horton WE, Spencer RG, Camacho NP.Fourier transform infrared imaging spectroscopic analysis of tissue engineered cartilage: histologic and biochemical correlations. J Biomed Opt. May-Jun;10(3):031105. 2005
Yang L, Carlson SG, McBurney D, Horton WE Jr.: Multiple signals induce endoplasmic reticulum stress in both primary and immortalized chondrocytes resulting in loss of differentiation, impaired cell growth, and apoptosis. J Biol Chem. Sep 2;280(35):31156-65. 2005
Yagi R, McBurney D, Horton WE Jr. : Bcl-2 positively regulates Sox9-dependent chondrocyte gene expression by suppressing the MEK-ERK1/2 signaling pathway.
J Biol Chem. Aug 26;280(34):30517-25. 2005
Reno PL, McBurney DL, Lovejoy CO, Horton WE Jr. Ossification of the mouse metatarsal: Differentiation and proliferation in the presence/absence of a defined growth plate. Anat Rec A Discov Mol Cell Evol Biol. Jan;288(1):104-18. 2005
J. G. M. Thewissen, M. J. Cohn, L. S. Stevens, S. Bajpai, J. Heyning, W. E. Horton Jr., Developmental Basis for Hind Limb Loss in Dolphins and Origin of the Cetacean Bodyplan. Accepted, Proceedings of the National Academy of Sciences 2006 May 30;103(22):8414-8. Epub 2006
Bradham, D.E., and W.E. Horton Jr. In vivo cartilage formation from growth factor modulated articular chondrocytes. Clinical Orthopaedics and Related Research 352: 239-249, 1998
Feng, L., P. Precht, R. Balakir, and W.E. Horton Jr. Decreased Bcl-2 expression is associated with articuclar chondrocyte apoptosis induced by serum withdrawal and retinoic acid. J. Cellular Biochemistry. 71: 302-309, 1998
Lixin, F., Balakir, R., Precht, P., Horton Jr., W.E.: Bcl-2 Regulates Chondrocyte Morphology & Aggrecan Gene Expression Independent of Caspase Activation and Full Apoptosis. J. Cell. Biochem. 74: 576-586, 1999
Murray, D., Precht, P., Balakir, R., and Horton Jr., W.E.: The Transcription Factor delta EF1 Binds to a Sequence in the 5’Flanking Region of the Col2a1 Gene and Can Repress Promoter Activity in Transfected Chondrocytes. J. Biol. Chem. 275: 3610-3618, 2000
Potter, K., Butler, J.J., Horton Jr., W.E., and Spencer, R.G.S.: Response of engineered cartilage tissue to biochemical agents as studied by proton magnetic resonance microscopy. Arthritis & Rheum. 43: 1580-1590, 2000
Adams, C.S., and Horton Jr., W.E.: Apoptosis and Bone Disease. In Mattson, M.P., Estus, S., and Rangnekar, V. (Eds): Programmed Cell Death Volume II. Elsevier Science B.V. 2001, pp. 271-313.
Lucchinetti, E., Adams, C. S., Horton Jr, W.E .and Torzilli, P.A.: Cartilage viability afterrepetitive loading: a preliminary report. Osteoarthritis and Cartilage 10: 71-81, 2002
Kinkel M. and Horton Jr., W.E.: Coordinate down-regulation of cartilage matrix gene expression in Bcl-2 deficient chondrocytes is associated with decreased sox-9 expression and decreased mRNA stability. J. Cell Biochem. 88: 941-953, 2003
Chen, C., Torzilli, P., Spencer, R.G.S., Fishbein, K., and Horton Jr., W.E.: Magnetic Resonance Microscopy of Bioreactor-Derived Hyaline Cartilage Correlated with Biochemical and Biomechanical Properties. Arthritis and Rheumatism. 48: 1047-1056, 2003.
Kinkel, M., Yagi, R, and Horton Jr., W.E.: Age-Related Expression Patterns of Bag-1 and Bcl-2 in Growth Plate and Articular Chondrocytes. Anatomical Records Anat Rec. 279A(2):720-728 2004
Yagi, R., Laverty, D., Weiner, S., Horton Jr., W.E. Intrajoint comparisons of gene expression patterns in human osteoarthritis suggests a change in chondrocyte phenotype Journal of Orthopaedic Research. 23: 1128-1138. 2005.
Horton Jr., WE, Yagi R., Laverty D., Weiner S. Overview of studies comparing human normal cartilage with minimal and advanced osteoarthritic cartilage. Clincial and Experimental Rheumatology, Jan-Feb;23(1):103-12 2005
Adamczyk, MJ. Weiner DS, Nugent A, McBurney D, and Horton Jr. WE: Increased chondrocyte apoptosis in growth plates from children with slipped capital femoral epiphysis. J. of Pediatric Orthopaedics. July/August;25(4):440-444 2005
Kim M, Bi X, Horton WE, Spencer RG, Camacho NP.Fourier transform infrared imaging spectroscopic analysis of tissue engineered cartilage: histologic and biochemical correlations. J Biomed Opt. May-Jun;10(3):031105. 2005
Yang L, Carlson SG, McBurney D, Horton WE Jr.: Multiple signals induce endoplasmic reticulum stress in both primary and immortalized chondrocytes resulting in loss of differentiation, impaired cell growth, and apoptosis. J Biol Chem. Sep 2;280(35):31156-65. 2005
Yagi R, McBurney D, Horton WE Jr. : Bcl-2 positively regulates Sox9-dependent chondrocyte gene expression by suppressing the MEK-ERK1/2 signaling pathway.
J Biol Chem. Aug 26;280(34):30517-25. 2005
Reno PL, McBurney DL, Lovejoy CO, Horton WE Jr. Ossification of the mouse metatarsal: Differentiation and proliferation in the presence/absence of a defined growth plate. Anat Rec A Discov Mol Cell Evol Biol. Jan;288(1):104-18. 2005
J. G. M. Thewissen, M. J. Cohn, L. S. Stevens, S. Bajpai, J. Heyning, W. E. Horton Jr., Developmental Basis for Hind Limb Loss in Dolphins and Origin of the Cetacean Bodyplan. Accepted, Proceedings of the National Academy of Sciences 2006 May 30;103(22):8414-8. Epub 2006
