Hans G. Folkesson, Ph.D.
Professor of Physiology and Pharmacology

Northeastern Ohio Universities
Colleges of Medicine and Pharmacy
4209 State Route 44, P.O. Box 95
Rootstown, Ohio 44272-0095
Phone: (330) 325-6436
E-Mail: hgfolkes@neoucom.edu

 

Education:

1992 Ph.D., Lund University, Lund Sweden
1986 B.Sc., Lund University, Lund, Sweden

 

Professional Experience:

Sept. 2007-Present Professor, Department of Integrative Medical Sciences, Northeastern Ohio Universities Colleges of Medicine and Pharmacy, Rootstown, OH.
July 2006-Aug. 2007 Professor, Department of Physiology and Pharmacology, Northeastern Ohio Universities College of Medicine, Rootstown, OH.
Jan. 2000-June 2006 Associate Professor, Department of Physiology and Pharmacology, Northeastern Ohio Universities College of Medicine, Rootstown, OH.
Jan. 2000-Present Graduate Faculty in Physiology, Kent State University, Kent, OH.
May 1995-Jan. 2000 Assistant Professor, Lund University, Lund, Sweden
June 1988 Research Assistant, Lund University, Lund, Sweden
Oct. 1986-March 1987 Research Assistant, Lund University, Lund, Sweden
Sept. 1998-Nov. 1998 Visiting Assistant Research Physiologist, University of California at San Francisco (UCSF)
April 1997-June 1997 Visiting Assistant Research Biologist, University of California at San Francisco (UCSF)
June 1996-Aug. 1996 Visiting Assistant Research Physiologist, University of California at San Francisco (UCSF)
July 1992-Aug. 1995 Post-Doctoral Research Fellow, University of California at San Francisco (UCSF)

 

Research Interests:

  • Development of ion and liquid transport mechanisms.

  • Use of RNAi technology to examine effects and regulation of channel proteins from specific gene silencing.

  • Passive and channel-regulated water permeability.

  • Aerosol delivery of protein and peptide drugs.

  • Mechanisms of neutrophil migration after acute lung injury.

 

Recent Publications:

Dr. Folkesson's publications listed in PubMed

Li T, Koshy S, and Folkesson HG. (2007) Involvement of αENaC and Nedd4-2 in the conversion from lung fluid secretion to fluid absorption at birth in the rat as assayed by RNA interference analysis. Am J Physiol Lung Cell Mol Physiol, 293: L1069-L1078.

Bhattacharjee R, Li T, Koshy S, Beard LL, Sharma K, Carter EP, Garat C, and Folkesson HG. (2007) Stimulation of MAP kinase pathways after maternal IL 1β exposure induces fetal lung fluid absorption in guinea pigs. Respir Res, 8:27: 1-8. (doi:10.1186/1465-9921-8-27)

Li T, Varadarajulu S, Beard LL, Yun J, and Folkesson HG. (2007) A non-inflammatory IL-1β-fragment (IL-1βFr) stimulates fetal lung fluid absorption in guinea pigs. J Pharmacol Exp Ther, 320: 877-884.

Maron MB, Folkesson HG, Stader SM, and Hodnichak CM. (2006) Impaired alveolar liquid clearance after 48 h isoproterenol infusion recovers spontaneously by 96 h of continuous infusio. Am J Physiol Lung Cell Mol Physiol, 291: L252-L256.

Su X, Robriquet L, Folkesson HG, and Matthay MA. (2006) Protective effect of endogenous β-adrenergic tone on lung fluid balance in acute bacterial pneumonia in mice. Am J Physiol Lung Cell Mol Physiol, 290: L769-L776.

Li T and Folkesson HG. (2006) RNA interference for αENaC inhibits rat lung fluid absorption in vivo. Am J Physiol Lung Cell Mol Physiol, 290: L649-L660.

     *Editorial about Li and Folkesson:Jain L and Eaton DC (2006) Alveolar fluid transport: a changing paradigm. Am J Physiol Lung Cell Mol Physiol 290: L646-L648.

Sakuma T, Gu X, Wang Z, Maeda S, Sugita M, Sagawa M, Osanai K, Toga H, Ware LB, Folkesson HG, and Matthay MA. (2006) Stimulation of alveolar epithelial fluid clearance in human lungs by exogenous epinephrine. Crit Care Med, 34: 676-681.

     *Editorial about Sakuma T et al.: Westphal M and Bone HG. (2006) Epinephrine stimulates pulmonary fluid clearance: More than just an epiphenomenon? Crit Care Med, 34: 907-908.

Folkesson HG, Chapin CJ, Beard LL, Ertsey R, Matthay MA, and Kitterman JA. (2006) Congenital diaphragmatic hernia prevents absorption of distal airspace fluid in late gestation rat fetuses. Am J Physiol Lung Cell Mol Physiol, 290: L478-L484.

Naugle JE, Olson ER, Zhang X, Mase SE, Pilati CF, Maron MB, Folkesson HG, Horne WI, Doane KJ, and Meszaros JG. (2006) Type VI collagen induces cardiac myofibroblast differentiation: implications for post-infarction remodeling. Am J Physiol Heart Circ Physiol, 290: H323-H330.

Nair PK, Li T, Bhattacharjee R, Ye X, and Folkesson HG. (2005) Oxytocin-induced preterm labor augments IL-1β-stimulated distal lung fluid absorption in fetal guinea pig lungs. Am J Physiol Lung Cell Mol Physiol, 289: L1029-L1038.

Maron MB, Folkesson HG, Stader SM, and Walro JM. (2005)PKA delivery to the distal lung airspaces increases alveolar liquid clearance after isoproterenol-induced alveolar epithelial PKA desensitization. Am J Physiol Lung Cell Mol Physiol, 289: L349-L354.