John Y.L. Chiang, Ph.D.
Professor of Biochemistry and Molecular Pathology

Northeastern Ohio Universities
Colleges of Medicine and Pharmacy
4209 State Route 44, P.O. Box 95
Rootstown, Ohio 44272-0095
Phone: (330) 325-6694
E-Mail: jchiang@neoucom.edu

 

Education:

1976 Ph.D., State University of New York at Albany, N.Y.
1969 B.S., National Taiwan Chung-Shing University, Taiwan

 

Professional Experience

1988-
present		 Professor of Biochemistry and Molecular Pathology, Department of Integrative Medical Sciences, Northeastern Ohio Universities Colleges of Medicine and Pharmacy, Rootstown, OH.
1983-1988 Associate Professor of Biochemistry and Molecular Pathology, Department of Biochemistry, Northeastern Ohio Universities College of Medicine, Rootstown, OH.
1978-
present		 Graduate Faculty, Cellular and Molecular Biology Program, Pharmacology Program, School of Biomedical Sciences, Kent State University.
1978-1983 Assistant Professor of Biochemistry and Molecular Pathology, Northeastern Ohio Universities College of Medicine, Rootstown, OH.
1976-1978 Postdoctoral Scholar (with M.J. Coon), Department of Biological Chemistry, The university of Michigan Medical School, Ann Arbor, Michigan.
1973-1976 Graduate Assistant (with T.E. King), Department of Chemistry, SUNY at Albany, New York.

 

Patents

  • Truncated human cholesterol 7α-hydroxylase, method of production and use therof. U.S. Patent #5,420,028, 5/30/1995, and European Patent #0648842, 2003.

  • Cholesterol 7α-hydroxylase gene regulatory elements and methods of using them. U.S. Patent #5,558,999, September 24, 1996; U.S. Patent #5,753,431, 5/19/1998.

  • Transgenic mice expressing human cholesterol 7α-hydroxylase. U.S. Patent #5,663,483, September 2, 1997.

  • Genomic DNA of human cholesterol 7α-hydroxylase, and methods of using it. U.S. patent #5,650,286, 7/22/1997; U.S. patent #5,677,159, 10/14/1997; U.S. patent #5,851,780, 12/22/1998.

  • Assay for agents that affect cholesterol 7α-hydroxylase expression and a characterization of its regulatory elements. U.S. patent #5,821,057, 10/13/1998.

 

Recent Publications

Dr. Chiang's publications listed in PubMed


Song, K.H. and Chiang, J.Y.L. Glucagons and cAMP inhibit cholesterol 7α-hydroxylase (CYP8B1)gene expression in human hepatocytes: discordant regulation of bile acid synthesis and gluconeogenesis. Hepatology, 43, 117-125 (2006).


Li, T., Chiang, J.Y.L. Maximal induction of CYP3A4 by PXR requires HNF4α, SCR-1, and PGC-1α, and suppression of SHP gene transcription. Drug Metab and Disp 34:756=764 (2006).


Song, K.H. and Chiang, J.Y.L. A prospero-related homeodomain protein (Prox1) is a novel coregulator of hepatocyte nuclear factor 4α (HNF4α). J Biol. Chem. 281, 10081-10088 (2006).


Shang, Q., L. Pan, M. Saumoy, J. YL Chiang, G.S. Tint, G. Salen, G. Xu. The stimulatory effect of LXRα is blocked by SHP despite the presence of a funtional LXRα binding site in the rabbit CYP7A1 promoter. J Lipid Res. 47:997-1004 (2006).


Li, T., A. Jahan, and J. YL Chiang. Bile acids and cytokines inhibit the human cholesterol 7α-hydroxylase gene via the JNK/cJun pathway. Hepatology, 43:1202-1210 (2006).


Li, T., X. Kong, E. Owsley, E. Ellis, S. Strom, and J.Y.L. Chiang. Insulin regulation of cholesterol 7α-hydroxylase expression in human hepatocytes: roles of forkhead box 01 and sterol regulatory element binding protein 1c. J. Biol. Chem. 281:28745-28754 (2006).


Li, T., W. Chen, and J.Y.L. Chiang PXR induces CYP27A1 and regulates cholesterol metabolism in the intestine. J. Lipid Res. 48:373-384 (2007).


Song, K.H., E. Ellis, S. Strom, and J.Y.L. Chiang Hepatocyte growth factor inhibits cholesterol 7α-hydroxylase expression in human hepatocytes.  Hepatology, 46:1993-2002 (2007).


T. Li and J.Y.L. Chiang A novel role of transforming growth factors β1 in transcriptional repression of human cholesterol 7α-hydroxylase gene. Gastroenterology 133:1660-1669 (2007).