Liya Yin, Ph.D.
Research Assistant Professor

Northeastern Ohio Universities
College of Medicine
4209 State Route 44, P.O. Box 95
Rootstown, Ohio 44272-0095
Phone: (330) 325-6521
E-Mail: lyin@neoucom.edu

 

Education:

 1998  Ph.D., Molecular Cardiology, Hubei Medical University
 1993  M.S., Biomedical Engineering, Hubei Medical University
 1990  M.D., Medicine, Hubei Medical University

 

Professional Experience:

2008-present

Research Assistant Professor,
Department of Integrative Medical Sciences, Northeastern Ohio Universities Colleges of Medicine and Pharmacy, Rootstown, OH

2006-2008 Assistant Researcher, Department of Medicine/Cardiology, University of California, Los Angeles, CA
2002-2006 Postgraduate Researcher, Cardiovascular Research Institute, University of California, San Francisco, CA
1999-2002  Postdoctoral Research Associate, Department of Biochemistry & Molecular Pharmacology, West Virginia University, Morgantown, WV 

 

Recent Publications:

Weinstein M, Yin L, Beigneux A, Davies B, Gin P, Estrada K, Melford, Fong L, Bensadoun A, and Young S. (2008)  Delayed release of lipoprotein lipase after intravenous heparin in GPIHBP1-deficient mice.  J Biol Chem, 283(50):34511-8

Gin P, Yin L, Davies BS, Weinstein M, Ryan R, Bensadoun A, Fong L, Young SG and Beigneux A. (2008)  The Acidic Domain of GPIHBP1 Is Important for the Binding of Lipoprotein Lipase and Chylomicrons.  J Biol Chem, 283(43):29554-62

Regard JB, Kataoka H, Cano DA, Camerer E, Yin L, Zheng YW, Scanlan TS, Hebrok M, Coughlin SR. (2007)  Probing cell type-specific functions of G(i) in vivo identifies GPCR regulators of insulin secretion.  J Clin Invest. 117:4034–43.

Yin L, Wang Y, Dridi S, Vinson C, Hillgartner FB. (2005) Role of CCAAT/enhancer-binding protein, histone acetylation, and coactivator recruitment in the regulation of malic enzyme transcription by thyroid hormone.  Mol Cell Endocrinol. 245:43-52.

Ruppel KM, Willison D, Kataoka H, Wang A, Zheng YW, Cornelissen I, Yin L, Xu SM, Coughlin SR. (2005)  Essential role for Galpha13 in endothelial cells during embryonic development.  Proc Natl Acad Sci U S A 102:8281-6.

Zhang Y, Yin L, Hillgartner FB. (2003)  SREBP-1 integrates the actions of thyroid hormone, insulin, cAMP, and medium-chain fatty acids on ACCalpha transcription in hepatocytes.  J Lipid Res. 44:356-68.

Park HJ, Begley U, Yin L, Hillgartner FB, Kotzka J, Muller-Wielnd D,Osborne TF, Galper JB. (2002)  Stimulation of Galpha (12) expression by sterol regulatory element binding proteins in cultured atrial cells.  Circulation. 106:1028 Suppl. S

Park HJ, Begley U, Kong D, Yu H, Yin L, Hillgartner FB, Osborne TF, Galper JB. (2002)  Role of sterol regulatory element binding proteins in the regulation of Galpha (i2) expression in cultured atrial cells.  Circ Res. 91(1):32-7.

Yin L, Zhang Y, Hillgartner FB. (2002)  Sterol regulatory element-binding protein-1 interacts with the nuclear thyroid hormone receptor to enhance acetyl-CoA carboxylase-alpha transcription in hepatocytes.  J Biol Chem. 277:19554-65.

Wang Y, Yin L, Hillgartner FB. (2001)  The homeodomain proteins PBX and MEIS1 are accessory factors that enhance thyroid hormone regulation of the malic enzyme gene in hepatocytes.  J Biol Chem. 276:23838-48.

Zhang Y, Yin L, Hillgartner FB. (2001)  Thyroid hormone stimulates acetyl-coA carboxylase-alpha transcription in hepatocytes by modulating the composition of nuclear receptor complexes bound to a thyroid hormone response element.  J Biol Chem. 276: 974-83.

Yin L, Zhang Y, Charron T, Hillgartner FB. (2000)  Thyroid hormone, glucagon, and medium-chain fatty acids regulate transcription initiated from promoter 1 and promoter 2 of the acetyl-CoA carboxylase-alpha gene in chick embryo hepatocytes.  Biochim Biophys Acta. 1517: 91-9.