Mark A. Simmons, Ph.D.
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| 1983 | Ph.D., Loyola University of Chicago, Chicago, IL. |
| 1976 | B.S., University of South Carolina, Columbia, SC. |
Professional Experience:
| 2000-Present | Professor, Department of Integrative Medical Sciences, Northeastern Ohio Universities Colleges of Medicine and Pharmacy, Rootstown, OH. |
| Dec. 2006-June 2007 | Visiting Scientist, Department of Neuroscience Biology, Astrazeneca Pharmaceuticals, Wilmington, DE. |
| June-July 2000 | Academic Visitor, Department of Pharmacology, University College London. |
| 1998-2000 | Research Scientist, Department of Veterans Affairs Medical Center, Huntington, WV. |
| 1995-2000 | Professor, Department of Pharmacology, Marshall University School of Medicine, Huntington, WV. |
| 1993-1994 | Senior Fellow in Neurobiology, Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, MO. |
| 1991-1995 | Associate Professor, Department of Pharmacology, Marshall University School of Medicine, Huntington, WV. |
| 1987-1991 | Assistant Professor, Department of Pharmacology, Marshall University School of Medicine, Huntington, WA. |
Research Interests:
- Behavioral, cellular and molecular neuropharmacology.
- Cellular and molecular mechanisms of neurotransmitter action.
- Coupling of membrane receptors to ion channels in nerve cells and cardiac muscle.
Recent Publications:
Dr. Simmons' publications listed in PubMed
Beard, D.J., Perrine, S.A., Phillips, E., Hoque, S., Conerly, S., Tichenor, C., Simmons, M.A. Young, J.K. Conformational comparisons of a series of tachykinin peptide analogs. Journal of Medicinal Chemistry 2007, 50:6501-6506.
Simmons, M.A. Functional selectivity of NK1 receptor signaling: peptide agonists can preferentially produce receptor activation or desensitization. Journal of Pharmacology & Experimental Therapeutics 2006 319:9079-13.
Simmons, M.A. Functional selectivity, ligand-directed trafficking, conformation specific agonism: what's in a name? Molecular Interventions, 5: 150-154, 2005.
Bennett, V.J., Perrine, S.A., and Simmons, M.A. Neurokinin-1 receptor resensitization results from a change in G protein coupling and not from receptor recycling. Journal of Pharmacology and Experimental Therapeutics, 313: 1347-1354, 2005.
Perrine, S.A. and Simmons, M.A. Tachykinin peptide-induced activation and desensitization of neurokinin 1 receptors. Peptides, 24:469-475, 2003.
Bennett, V.J., Perrine, S.A. and Simmons, M.A. A novel mechanism of neurokinin-1 receptor resensitization. Journal of Pharmacology and Experimental Therapeutics, 303:1155-1162, 2002.
Bennett, V.J. and Simmons, M.A. Analysis of fluorescently-labeled substance P analogs: binding, imaging and receptor activation. BMC Chemical Biology 1:1 (12 pp.). 2001.
Perrine, S. A., Whitehead, T.L., Hicks, R.P., Szarek, J. L., Krause, J. E. and Simmons, M. A. Solution structure in SDS micelles and functional activity at the bullfrog substance P receptor of ranatachykinin peptides. Journal of Medicinal Chemistry, 43:1741-1753, 2000.
Simmons, M. A. and Schneider, C. R. Regulation of M-Type potassium current by intracellular nucleotide phosphates. Journal of Neuroscience, 18:6254-6260, 1998.
Simmons, M. A., Brodbeck, R. M., Karpitskiy, V. V., Schneider, C. R., Neff, D. P. A. and Krause, J. E. Molecular characterization and functional expression of a substance P receptor from the sympathetic ganglion of Rana catesbeiana. Neuroscience, 79:1219-1229,1997.
Simmons, M. A., Schneider, C. R. and Krause, J. E. Regulation of the responses to gonadotropin releasing hormone, muscarine, and substance P in sympathetic neurons by changes in cellular constituents and intracellular application of peptide fragments of the substance P receptor. Journal of Pharmacology and Experimental Therapeutics, 271:581-589, 1994.
Simmons, M. A. and Mather, R. J. Intracellular guanosine-5'-O-(2-thiodiphosphate) alters the dynamics of receptor-mediated responses in bullfrog sympathetic neurons. Molecular Pharmacology, 41:527-534, 1992.
Simmons, M. A., Becker, J. B. and Mather, R. J. Desensitization of the inhibition of the M current in sympathetic neurons: effects of ATP analogs, polyanions and multiple agonist applications. Neuron, 4:557-562, 1990.
Simmons, M. A. and Hartzell, H. C. Role of phosphodiesterase in regulation of calcium current in isolated cardiac myocytes. Molecular Pharmacology, 33:664-671, 1988.
Simmons, M. A., Creazzo, T. and Hartzell, H. C. A time-dependent and voltage-sensitive K+current in single cells from frog atrium. Journal of General Physiology, 88:739-755, 1986.
Simmons, M. A. The complexity and diversity of synaptic transmission in the prevertebral sympathetic ganglia. Progress in Neurobiology, 24:43-93, 1985.
