William M. Chilian, Ph.D.
Professor of Physiology and Pharmacology, and Chairman

Northeastern Ohio Universities
College of Medicine
4209 State Route 44, P.O. Box 95
Rootstown, Ohio 44272-0095
Phone: (330) 325-6426
E-Mail: wchilian@neoucom.edu

 

Education:

1980 Ph.D. University of Missouri, Columbia, Missouri
1976 M.S., Texas Tech University, Lubbock, Texas
1974 B.A., Honors in Biology, St. Olaf College, Northfield, Minnesota

 

Professional Experience:

June 2007-present Professor and Chairman of Department of Integrative Medical Sciences, Northeastern Ohio Universities Colleges of Medicine and Pharmacy, Rootstown, OH
June 2002-May 2007 Kenneth A. Ardoin/Pfizer Superchair of Basic Cardiovascular Research, Department of Physiology, LSU Health Sciences Center, New Orleans, LA
June 2002-May 2007 Professor, Department of Physiology, LSU Health Sciences Center, New Orleans, LA
April 2000-May 2002 Associate Director, Cardiovascular Center, Medical College of Wisconsin, Milwaukee, WI
January 1996-May 2002 Professor, Department of Physiology, Medical College of Wisconsin, Milwaukee, WI
September 1995-December 1995 Professor, Department of Medical Physiology, College of Medicine, Texas A &amp M University Health Science Center
September 1993-August 1994 Visiting Scientist, Department of Experimental Cardiology, Max-Planck Institute for Clinical Physiology, Bad Nauheim, Germany
September 1991-August 1995 Assocaite Professor, Department of Medical Physiology, College of Medicine, Texas A &amp M University Health Science Center
January 1987-August 1991 Assistant Professor, Department of Medical Physiology, College of Medicine, Texas A &amp M University
July 1982-December 1986 Assistant Research Scientist, Department of Internal Medicine and the Cardiovascular Center, University of Iowa
July 1983-June 1984 Adjunct Associate, Department of Physiology and Biophysics, University of Iowa
September 1980-June 1982 Research Fellow, Department of Internal Medicine and the Cardiovascular Center, University of Iowa

 

Recent Publications

Dr. Chilian's publications listed in PubMed

Saitoh S, Zhang C, Tune JD, Potter B, Kiyooka T, Rogers PA, Knudson JD, Dick GM, Swafford A, and Chilian WM. Hydrogen peroxide: a feed-forward dilator that couples myocardial metabolism to coronary blood flow. Arterioscler Thromb Vasc Biol 26: 2614-2621, 2006.

Rogers PA, Kiyooka T, and Chilian WM. Is there a need for another model on the pulsatile nature of coronary blood flow? Am J Physiol Heart Circ Physiol 291: H1034-1035, 2006.

Rogers PA, Dick GM, Knudson JD, Focardi M, Bratz IN, Swafford AN, Jr., Saitoh S, Tune JD, and Chilian WM. H2O2-induced redox-sensitive coronary vasodilation is mediated by 4-aminopyridine-sensitive K+ channels. Am J Physiol Heart Circ Physiol 291: H2473-2482, 2006.

Picchi A, Gao X, Belmadani S, Potter BJ, Focardi M, Chilian WM, and Zhang C. Tumor necrosis factor-alpha induces endothelial dysfunction in the prediabetic metabolic syndrome. Circ Res 99: 69-77, 2006.

Sato M, Cismowski MJ, Toyota E, Smrcka AV, Lucchesi PA, Chilian WM, and Lanier SM. Identification of a receptor-independent activator of G protein signaling (AGS8) in ischemic heart and its interaction with Gbetagamma. Proc Natl Acad Sci U S A 103: 797-802, 2006.

Zhang C, Xu X, Potter BJ, Wang W, Kuo L, Michael L, Bagby GJ, and Chilian WM. TNF-alpha contributes to endothelial dysfunction in ischemia/reperfusion injury. Arterioscler Thromb Vasc Biol 26: 475-480, 2006.

Saitoh S, Kiyooka T, Rogers PA, Dick GM, Rocic P, Swafford A, Viswanathan C, Park Y, Zhang C, and Chilian WM. Redox-Dependent Coronary Metabolic Dilation. Am J Physiol Heart Circ Physiol 2007.

Gao X, Xu X, Belmadani S, Park Y, Tang Z, Feldman AM, Chilian WM, and Zhang C. TNF-alpha contributes to endothelial dysfunction by upregulating arginase in ischemia/reperfusion injury. Arterioscler Thromb Vasc Biol 27: 1269-1275, 2007.

Hattan N, Chilian WM, Park F, and Rocic P. Restoration of coronary collateral growth in the Zucker obese rat: impact of VEGF and ecSOD. Basic Res Cardiol 102: 217-223, 2007.

Rocic P, Kolz C, Reed R, Potter B, and Chilian WM. Optimal reactive oxygen species concentration and p38 MAP kinase are required for coronary collateral growth. Am J Physiol Heart Circ Physiol 292: H2729-2736, 2007.

Focardi M, Dick GM, Picchi A, Zhang C, and Chilian WM. Restoration of coronary endothelial function in obese Zucker rats by a low-carbohydrate diet. Am J Physiol Heart Circ Physiol 292: H2093-2099, 2007.

Gao X, Belmadani S, Picchi A, Xu X, Potter BJ, Tewari-Singh N, Capobianco S, Chilian WM, and Zhang C. Tumor necrosis factor-alpha induces endothelial dysfunction in Lepr(db) mice. Circulation 115: 245-254, 2007.

Rogers PA, Chilian WM, Bratz IN, Bryan RM, Jr., and Dick GM. H2O2 activates redox- and 4-aminopyridine-sensitive Kv channels in coronary vascular smooth muscle. Am J Physiol Heart Circ Physiol 292: H1404-1411, 2007.