William J. Landis, Ph.D.
Professor of Biochemistry and Molecular Pathology

Northeastern Ohio Universities
College of Medicine
4209 State Route 44, P.O. Box 95
Rootstown, Ohio 44272-0095
Phone: (330) 325-6685
E-Mail: wlandis@neoucom.edu

 

Education:

1972 Ph.D., Massachusetts Institute of Technology
1967 M.S., Massachusetts Institute of Technology
1965 B.S., University of Massachusetts, Amherst

 

Professional Experience:

June 2007-present Professor, Department of Integrative Medical Sciences, Northeastern Ohio Universities Colleges of Medicine and Pharmacy, Rootstown, OH.
2005-2007 Professor of Immunology, Microbiology, and Biochemistry, Northeastern Ohio Universities College of Medicine, Rootstown, OH.
2000-Present Adjunct Professor, Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH.
1999-Present Professor of Orthopaedic Surgery, Northeastern Ohio Universities Colleges of Medicine and Pharmacy, Rootstown, OH.
1999-2008 Adjunct Professor, Department of Biochemistry, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA.
1999-Present Adjunct Professor, Department of Biomedical Engineering, University of Akron, Akron, OH.
1999-Present Full member of the graduate faculty, Kent State University, Kent, OH.
1998-2001 Special member of the graduate faculty, University of Colorado, Boulder, CO.
1998-2001 Lecturer in Orthopedic Surgery, Harvard Medical School, Boston, MA.
1998-2005 Professor and Chair, Department of Biochemistry and Molecular Pathology, Northeastern Ohio Universities College of Medicine, Rootstown, OH. 
1996-1998 Associate Professor of Orthopedic Surgery, Harvard Medical School, Boston, MA.
1988-1989 Fulbright Scholar, The Weizmann Institute of Science, Rehovot, Israel.
1984-1996 Associate Professor of Orthopaedic Surgery (Anatomy and Cellular Biology), Laboratory for Skeletal Disorders and Rehabilitation, Harvard Medical School, Boston, MA.
1981-1984 Assistant Professor of Orthopaedic Surgery (Anatomy), Laboratory for Skeletal Disorders and Rehabilitation, Harvard Medical School, Boston, MA.
1974-1981 Research Associate in Orthopaedic Surgery (Anatomy), Harvard Medical School, Boston, MA.
1972-1974 Associate in Orthopaedic Surgery, Harvard Medical School, Boston, MA.

 

Research Interests:

  • Mineral-matrix structure and interaction in normal (bone, calcifying cartilate and tendon, enamel, dentin, and cementum) and abnormal (osteogenesis imperfecta, osteoporosis, osteopetrosis) vertebrate tissues.

  • Bone, cartilage, and tendon biochemistry.

  • Tissue engineering of calcified tissues.

  • Effects of mechanical, gravitational, and electromagnetic forces on calcified tissues.

  • Calcium transport in calcification.

 

Recent Publications:

Dr. Landis' publications listed in PubMed

Scharschmidt T, Jacquet R, Laskovski J, Lowder E, Weiner S, Landis WJ. Analysis of human osteoarthritic connective tissue by laser capture microdissection and QRT-PCR. Connective Tissue Research 2007;48:316-323.

Chesnick I, Avallone F, Leapman R, Landis WJ, Eidelman N, Potter K. Evaluation of bioreactor cultivated bone by magnetic resonance microscopy and FTIR micro-spectroscopy. Bone 2007;40:904-912.

Schoenfeld A, Landis WJ, Kay D. Meniscal tissue engineering. Am J Orthop. In press, 2007.

Hjorten R, Hansen U, Underwood RA, Telfer HE, Fernandes RJ, Krakow D, Sebald E, Wachsmann-Hogiu S, Bruckner P, Jacquet R, Landis WJ, Byers PH, Pace JM. Type XXVII collagen at the transition of cartilage to bone during skeletogenesis. Bone 2007;41:535-542.

Siperko LM, Jacquet R, Landis WJ. Modified aminosilane substrates to evaluate osteoblast attachment, growth and gene expression in vitro. J Biomed Mater Res 2006;78A:808-822.

Isogai N, Kusuhara H, Ikada Y, Otani H, Jacquet R, Hillyer J, Lowder E, Landis WJ. Comparison of different chondrocytes for use in tissue engineering of cartilage model structures. Tissue Engin 2006;12:691-703.

Landis WJ, Silver FH, Freeman JW. Collagen as a scaffold for biomimetic mineralization of vertebrate tissues. J Mater Chem 2006;16:1495-1503 (Feature article and with journal cover image).

Potter K, Sweet DE, Anderson P, Isogai N, Asamura S, Kusuhara H, Landis WJ. Non-invasive studies of tissue-engineered phalanges by magnetic resonance microscopy and x-ray microtomography. Bone 2006;38:350-358.