David D. Allen, R.Ph. Ph.D. Dean of Pharmacy Professor of Pharmaceutical Sciences, College of Pharmacy Professor of Physiology/Pharmacology, College of Medicine Northeastern Ohio Universities College of Pharmacy 4209 St. Rt. 44, P.O. Box 95 Rootstown, Ohio 44272-0095 Phone: (330) 325-6461 Fax: (330) 325-5930 Email: dallen@neoucom.edu

David D. Allen, R.Ph., Ph.D., is the founding dean of pharmacy and professor of pharmaceutical sciences at the Northeastern Ohio Universities College of Pharmacy and professor of physiology and pharmacology in the Northeastern Ohio Universities College of Medicine. He received his bachelor's degree in pharmacy at the University of Kentucky and then worked in community pharmacy for several years before returning to the University of Kentucky to earn his doctorate in pharmaceutical sciences. In addition, Allen served as an intramural research training award postdoctoral fellow at NIH in Bethesda, Maryland. He has had grant support for his research from international, national, state and local funding sources, including the NIH, the American Heart Association, the American Association of Colleges of Pharmacy, the Chilean government and industrial sources. Most recently, he served as Associate Dean of Curricular Affairs at the Texas Tech University Health Sciences Center School of Pharmacy in Amarillo, Texas. Allen has published 65 peer-reviewed articles, 34 professional publications, 80 abstracts and presented his work over 130 times across the United States and abroad.

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Selected Publications:

Lockman P.R., Geldenhuys W.J., Manda V., Thomas F., Crooks P.A., Dwoskin L.P. and Allen D.D. Carrier mediated transport at the blood-brain barrier for the quaternary ammonium nicotinic receptor antagonist, N,N'-dodecyl-bis-picolinium bromide (bPiDDB). Journal of Pharmacology and Experimental Therapeutics. Accepted for publication.

Deuther-Conrad W., Patt J.T., Lockman P.R., Allen D.D., Patt M., Schildan A., Sabri O., Ganapathy V., Brust P., Steinbach J. In Vivo Evaluation of the Nicotinic Acetylcholine Receptor Ligand [18F]Norchloro-fluoro-homoepibatidine (NCFHEB). European Neuropsychopharmacology. Accepted for publication.

Gaasch J.A., Geldenhuys W.J., Lockman P.R., Allen D.D. and Van der Schyf C.J. Voltage-gated calcium channels provide an alternate route for iron uptake in neuronal cell cultures. Neurochemical Research. In Press.

Gaasch J.A., Lockman P.R., Geldenhuys W.J., Allen D.D., and Van der Schyf C.J. Brain Iron Toxicity: Differential Responses of Astrocytes, Neurons, and Endothelial Cells. Neurochemical Research. In Press.

Geldenhuys W.J., Van der Schyf C.J., Hayes M. and Allen D.D. Receptor surface models in the classroom: Introducing molecular modeling to students in a 3D world. Journal of Chemical Education. 84: 979-982. June, 2007.

Schugar H., Green D.E., Bowen M.L., Scott L.E., Storr T., Böhmerle K., Thomas F., Allen D.D., Lockman P.R., Merkel M., Thompson K.H., and Orvig C. Combating Alzheimer's Disease by Designed Multifunctional Molecules for Metal Passivation. Angewandte Chemie Int. Ed. 46: 1716-1718. 2007. Angewandte Chemie. 119: 1746-1748. 2007.

Opazo P., Saud K., de Saint Pierre M., Cárdenas A.M., Allen D.D., Segura-Aguilar J., Caviedes R., and Caviedes P. Knockdown of amyloid precursor protein normalizes choline uptake and acetylcholine release in a cell line derived from the cerebral cortex of a trisomy 16 mouse, an animal model of Down syndrome. Journal of Neuroscience Research. 84: 1303-1310. 2006.

McCall K.L., Allen D.D. and Fike D. Correlation between advanced college coursework and academic success in pharmacy school. American Journal of Pharmaceutical Education. 70: 106. 2006.

Koziara J.M., Lockman P.R, Allen D.D., and Mumper R.J. The Blood-Brain Barrier and Brain Drug Delivery. Invited Review for the Journal of Nanoscience and Nanotechnology. Special Issue: "Nanotechnology in Advanced Drug Delivery." 2006. 6: 2712-2735. 2006.

Saud K., Arriagada C., Cárdenas A.M., Shimahara T., Allen D.D., Caviedes R., Caviedes P. Neuronal dysfunction in Down syndrome: Contribution of neuronal models in cell culture. Journal of Physiology (Paris). 99:201-201. 2006.

Lockman P.R., Gaasch J.A., Van der Schyf C.J. and Allen D.D. Nicotine exposure does not alter plasma to brain choline transfer. Neurochemical Research. 31: 503-508. 2006.

Geldenhuys W.J., Gaasch K.E., Watson M., Allen D.D., and Van der Schyf C.J. Optimizing the use of open-source software applications: How to integrate available computer modeling options in drug discovery. Drug Discovery Today. 11: 127-132. 2006.

Paulson J.R., Roder K.E., McAfee G., Allen D.D., Van der Schyf C.J., and Abbruscato T.J. Tobacco smoke chemicals attenuate brain-to-blood potassium transport mediated by Na,K,2Cl-cotransporter during hypoxia-reoxygenation. Journal of Pharmacology and Experimental Therapeutics. 316: 248-254. 2006.

Allen D.D. and Geldenhuys W.J. Molecular modeling of blood-brain barrier nutrient transporters: In silico basis for evaluation of potential drug delivery to the central nervous system. Life Sciences.78: 1029-1033. 2006.

Lockman P.R., Robbertse G., Geldenhuys W.J., Van der Schyf C.J., Abbruscato T.J., and Allen D.D. Brain uptake kinetics of nicotine and cotinine after chronic nicotine exposure. Journal of Pharmacology and Experimental Therapeutics. 314: 636-642. 2005.

Allen D.D., Caviedes R., Cardenas A.M., Shimahara T., Segura-Aguilar J. and Caviedes P. Cell lines as in vitro models for drug screening and toxicity studies. Drug Development and Industrial Pharmacy. 31: 747-758. 2005.

Geldenhuys W.J., Lockman P.R., Nguyen T.H, Van der Schyf C.J., Crooks P.A., Dwoskin L.P. and Allen D.D. 3D-QSAR study of N-n-alkylnicotinium analogs at the blood-brain barrier choline transporter. Bioorganic & Medicinal Chemistry. 13: 4253-4261. 2005.

Lockman P.R., Van der Schyf C.J., Abbruscato T.J. and Allen D.D. Chronic nicotine exposure alters blood-brain barrier permeability and diminishes brain uptake of methyllycaconitine. Journal of Neurochemistry. 94: 37-44. 2005.

Koziara J.M., Lockman P.R., Allen D.D. and Mumper R.J. In situ blood-brain barrier transport of nanoparticles. Pharmaceutical Research. 20: 1772-1778. 2003.

Allen D.D. and Lockman P.R. Invited review. The blood-brain barrier choline transporter as a brain drug delivery vector. Life Sciences. 73: 1609-1615. 2003.

Lockman P.R., Koziara J., Paulson J.R., Roder K.E., Abbruscato T.J., Mumper R.J. and Allen D.D. In vivo and in vitro assessment of baseline blood-brain barrier parameters in the presence of novel nanoparticles. Pharmaceutical Research. 20: 705-713. 2003.

Allen D.D., Lockman P.R., Roder K.E., Dwoskin L.P and Crooks P.A. Active transport of high affinity choline and nicotine analogs into the central nervous system by the blood-brain barrier choline transporter. Journal of Pharmacology and Experimental Therapeutics. 304:1268-1274. 2003.

Allen D.D., Nadesan B., Lee J.W., Bickel U., Haase M.R. and Arif A. Evaluation of novel teaching approaches in the Texas Tech University HSC School of Pharmacy elective, Drugs of Abuse. Journal of Pharmacy Teaching. 10: 1-16. 2002.

Lockman P.R. and Allen D.D. Invited Review. The transport of choline: A review. Drug Development and Industrial Pharmacy. 28(7): 749-771. 2002.

Lockman P.R., Mumper R.J., Khan M.A. and Allen D.D. Nanoparticle technology for drug delivery across the blood-brain barrier. Drug Development and Industrial Pharmacy. 28(1): 1-13. 2002.

Allen D.D. and Bond C.A. Prepharmacy predictors of success in Pharmacy School: Grade point averages, pharmacy college admissions test, communication abilities, and critical thinking skills. Pharmacotherapy.21: 842-849. 2001.

Allen D.D. and Smith Q.R. Characterization of the blood-brain barrier choline transporter using the in situ brain perfusion technique. Journal of Neurochemistry. 76: 1032-1041. 2001.

Allen D.D., Martin J., Arriagada C., Cardenas A.M., Rapoport S.I., Caviedes R. and Caviedes P. Impaired cholinergic function in cell lines derived from the cerebral cortex of normal and trisomy 16 mice. European Journal of Neuroscience. 12: 3259-3264. 2000.

Metting T.L., Burgio D.E., Terry A.V., Beach J.W., McCurdy C.R. and Allen D.D. Inhibition of choline uptake by isoarecolone and lobeline derivatives: Implications for potential vector mediated brain drug delivery. Neuroscience Letters. 258: 25-28. 1998.

Allen D.D., Galdzicki Z., Rapoport S.I., Brining S. and Smith Q.R. Beta-Amyloid induced increase in choline flux across PC12 cell membranes. Neuroscience Letters. 234: 1-3. 1997.

Allen D.D., Orvig C. and Yokel R.A. Evidence for Energy-dependent Transport of Aluminum at the Blood-Brain Barrier. Toxicology. 98: 31-39, 1995.

Allen D.D. and Yokel R.A. Dissimilar aluminum and gallium permeation of the blood-brain barrier demonstrated by in vivo microdialysis. Journal of Neurochemistry. 58(3): 903-908, 1992.