Anupam Bishayee, B.Pharm., M.Pharm., Ph.D. Assistant Professor of Pharmaceutical Sciences Northeastern Ohio Universities College of Pharmacy 4209 St. Rt. 44, P.O. Box 95 Rootstown, Ohio 44272-0095 Phone: (330) 325-6449 Fax: (330) 325-5936 Email: abishayee@neoucom.edu

Dr. Bishayee joined the Pharmaceutical Sciences faculty in August, 2007. He received his Bachelor of Pharmacy, Master of Pharmacy, and Ph.D. from the Jadavpur University, a premier educational and research institution in Calcutta, India.

In 1997, he moved to the University of Medicine and Dentistry of New Jersey (UMDNJ), the largest health sciences university in the nation, as a post-doctoral fellow where he worked in the Departments of Pharmacology and Physiology, Pathology and Laboratory Medicine, and Radiology (Radiation Research). He was attached to the UMDNJ for more than ten years in various research, teaching, and scientific administrative positions before joining the Northeastern Ohio Universities College of Pharmacy.

Dr. Bishayee has been teaching in several courses of the ongoing Pharm.D. curriculum. His teaching interests include Pharmaceutics (including Radiopharmacy), Pharmacokinetics, Pharmacology, and Natural Products/Pharmacognosy. Dr. Bishayee has been engaged in medicinal plants and biomedical research for more than last 15 years.  He is an author of over 49 research articles in peer-reviewed journals and 2 book chapters, and presented more than 20 papers at national and international scientific meetings. He is an active member of various organizations devoted to scientific research and pharmacy education.

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Cancer is the second most common cause of death in the United States as well the entire world, exceeded only by heart disease. Currently, one of the four deaths in the US is caused by cancer. Dietary behavior seems to be an important modifiable determinant for the risk of cancer. Natural dietary agents, including fruits, vegetables and spices, have been shown to reduce the risk of developing cancer. Although various epidemiological and experimental evidence supports the premise that various plant-derived agents play an important role in cancer chemoprevention, a very small fraction of all plant species (~1%) has been screened for bioactivity. My present research focuses on the study of several dietary constituents, phytochemicals, and related synthetic compounds for prevention and treatment of cancer with the understanding of related mechanisms of action.

Dr. Bishayee's publications listed in PubMed (partial list).

Book Chapters:

Bishayee, A., and Chatterjee, M.: Protective effect of Diospyros peregrina root extract against carbon tetrachloride-induced hepatotoxicity in mice. In, Ayurveda Vistas (edited by Kulkarni, P.H.), Sri Satguru Publications, New Delhi, pp. 154-158 (2001)

Chatterjee, M., and Bishayee, A.: Vanadium - a new tool for cancer prevention. In, Vanadium in the Environment, Part 2: Health Effects (edited by Nriagu, J.O.), John Wiley and Sons Inc., New York, pp. 347-390 (1998)

Selected Publications:

Rabi, T., and Bishayee, A.: Terpenoids and breast cancer chemoprevention (review). Breast Cancer Research and Treatment, in press (2008) [DOI: 10.107/s10549-008-0118-y]

Howell, R.W., and Bishayee, A.: Bystander effects caused by nonuniform distributions of DNA-incorporated ¹²⁵I. Micron, 33, 127-132 (2002)

Saha, B.K., Bishayee, A., Kanjilal, N.B., and Chatterjee, M.: 1a,25-Dihydroxyvitamin D₃ inhibits hepatic chromosomal aberrations, DNA strand breaks and specific DNA adducts during rat hepatocarcinogenesis.,25-Dihydroxyvitamin D inhibits hepatic chromosomal aberrations, DNA strand breaks and specific DNA adducts during rat hepatocarcinogenesis. Cellular and Molecular Life Sciences, 58, 1141-1149 (2001)

Bishayee, A., Rao, D.A., and Howell, R.W.: Radiation protection by cysteamine against the lethal effects of intracellularly localized Auger electron, a-, and ß-particle emitting radionuclides. Acta Oncologica, 39, 713-720 (2000)

Bishayee, A., Rao, D.V., Srivastava, S.C., and Howell, R.W.: Marrow-sparing effects of Sn-117m(4+)DTPA for radionuclide therapy of cancer in bone. Journal of Nuclear Medicine, 41, 2043-2050 (2000)

Bishayee, A., Oinam, S., Basu, M., and Chatterjee, M.: Vanadium chemoprevention of 7,12-dimethylbenz(a)anthracene-induced rat mammary carcinogenesis: probable involvement of representative hepatic phase I and II xenobiotic metabolizing enzymes. Breast Cancer Research and Treatment, 63, 133-145 (2000)

Bishayee, A., Sarkar, A., and Chatterjee, M.: Further evidence for chemopreventive potential of beta-carotene against experimental carcinogenesis: diethylnitrosamine-initiated and phenobarbital-promoted hepatocarcinogenesis is prevented more effectively by beta-carotene than retinoic acid. Nutrition and Cancer, 37, 89-98 (2000)

Bishayee, A., Roy, S., and Chatterjee, M.: Characterization of selective induction and alteration of xenobiotic biotransforming enzymes by vanadium during diethylnitrosamine-induced chemical rat liver carcinogenesis. Oncology Research, 11, 41-53 (1999)

Bishayee, A., Beguinot, L., and Bishayee, S.: Phosphorylation of tyrosine 992, 1068, and 1086 is required for conformational change of the human epidermal growth factor receptor C-terminal tail. Molecular Biology of the Cell, 10, 525-536 (1999)

Bishayee, A., Kulkarni, S.P., Roy, K., and Chatterjee, M.: Alterations in total iron, zinc and calcium levels and its influence on the hepatic activities of gamma-glutamyl transferase and glucose-6-phosphatase in the host bearing transplantable murine lymphoma. Cancer Investigation, 16, 231-236 (1998)

Bishayee, A., Karmakar, R., Mandal, A., Kundu, S.N., and Chatterjee, M.: Vanadium-mediated chemoprotection against chemical rat hepatocarcinogenesis: reflection in haematological and histological characteristics. European Journal of Cancer Prevention, 6, 58-70 (1997)

Bishayee, A., Banik, S., Marimuthu, P., and Chatterjee, M.: Vanadium-mediated suppression of diethylnitrosamine-induced chromosomal aberrations in rat hepatocytes and its correlation with induction of hepatic glutathione and glutathione S-transferase. International Journal of Oncology, 10, 413-423 (1997)