Lois-May Bezuidenhout, B.Pharm., M.Sc. Thangaiyan Rabi, Ph.D.
Ms. Bezuidenhout joined the department of Pharmaceutical Sciences in September, 2006. She earned her B.Pharm and M.Sc. degrees from the North West University in South Africa and is currently enrolled for her Ph.D. in medicinal chemistry at the same University. Her research field focuses on neurodegeneration and syntheses of novel multimechanistic drugs for the treatment or prevention of neurodegenerative diseases. Education:
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| 2006-present | Research Technician, Department of Pharmaceutical Sciences, Northeastern Ohio Universities College of Pharmacy, Rootstown, OH |
| 2006 |
Research Technician, Department of Pharmaceutical Sciences, Texas Tech University Health Sciences Center School of Pharmacy, Amarillo, TX |
| 2004-2006 | Teaching Assistant, Department of Pharmaceutical Chemistry, North-West University, Potchefstroom, South Africa |
Research Interests:
Drug discovery utilizing synthetic organic chemistry and pharmacological evaluation. Current focus is on novel polycyclic multimechanistic drugs.Presentations:
Bezuidenhout, L., Geldenhuys, W.J. and Van der Schyf, C.J. Polycyclic amine derivatives: The synthesis of triquinylamines as calcium modulators. Annual ACS meeting (2007), Chicago, IL (Poster session).Bezuidenhout, L., Geldenhuys, W.J.and Van der Schyf, C.J. Polycyclic amine derivatives: The synthesis of triquinylamines as calcium modulators. Research Day (2007), Kent State University Graduate School of Biomedical Sciences, Kent, OH (Poster session).
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Rabi Thangaiyan, Ph.D. Email: trabi@neoucom.edu |
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Dr. Rabi joined the Department of Pharmaceutical Sciences in December, 2007. He earned his B.Sc. from Madurai-Kamaraj University, Madurai, India; M.Sc. from Gorakhpur University, Gorakhpur, India; Ph.D. from Banaras Hindu University, Varanasi, India. His area of research focuses on development of novel cancer chemopreventive and therapeutic drugs.
Education:
| 1995 | Ph.D. in Cancer Biology from Banaras Hindu University, Varanasi, India. |
| 1987 | M.Sc. Zoology, Gorakhpur University, Gorakhpur, India |
| 1982 | B.Sc. Zoology, Chemistry, Botany, Madurai-Kamaraj University, Madurai, India |
Professional Experience:
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2007-present |
Research Assistant, Department of Pharmaceutical Sciences, Northeastern Ohio Universities College of Pharmacy, Rootstown, OH |
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2006-2007 |
Research Associate, Department of Urology, Case Western Reserve University, Cleveland, OH |
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2004-2006 |
NIH/NCI Research Scholar, Department of Cancer Biology, Cleveland Clinic Lerner Research Institute, Cleveland, OH |
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2004 |
Chief, Drug Analysis and Research Laboratory, Siddha Medicines Manufacturers, Neyyoor, India |
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2003 |
Lecturer, Department of Genetics and Molecular Biology, Sankara Nethralaya Medical Research Foundation, Chennai, India |
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2001-2002 |
Visiting Scientist, Department of Pathology, Miami Children's Hospital, Miamia, FL |
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1998-2001 |
Research Associate, Division of Radiobiology, Regional Cancer Centre, Trivandrum, India |
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1997 |
Research Associate, Department of Microbiology, Madras University, Chennai, India |
Selected Research Interests:
To develop potential anticancer drugs based on targeting growth factor signal transduction, cell cycle, angiogenesis and apoptosis pathways.Publications:
Rabi T., Ramachandram C, Fonseca HB, Alomo A, Melnick SJ, Escalon E. (2003) Novel drug amooranin induces apoptosis through caspase activity in human breast carcinoma cell lines. Breast Cancer Res Treat. Aug; 80 (3):321-330.
Ramachandram C, Rabi T., Fonseca HB, Alomo A, Melnick SJ, Escalon E. (2003) Novel plant triterpenoid drug amooranin oercomes multidrug resistance in human leukemia and colon carcinoma cell lines. Int J Cancer 105 (6)784-789.
Rabi T., Wang, L., Banerjee, S. (2007) Novel Triterpenoid 25-Hydroxy-3-oxoolean-12-en-28-oic acid induces growth arrest and apoptosis in breast cancer cells. Breast Cancer Res Treat. Jan.; 101 (1):27-36.
Wang, L., Battacharya, N., Rabi, T., Banerjee, S. (2007) Mammary carcinogenesis of transgenic mice expressing a dominant-negative mutant of DNA polymerase beta in mammary glands. Carcinogenesis Jun.; 28 (6)1356-1363.
Rabi T., Banerjee, S. (2007) Novel synthetic triterpenoid AMR-Me induces apoptosis through JNK and p38 MAPK pathways in MCF-7 human breast cancer cells. Mol Carcinog (in press).
Rabi T., Gupta, S. (2008) Dietary terpenoids in prostate cancer chemoprevention (review). Front Biosci 13:3457-3469.
