| DATE | CAGING | BREEDING | RESULTS | COMMENTS |
May 08
| C | N | V-150 A: Positive for Simian Virus 5 (SV5). | Negative for all other tests. No fecal flotation test was performed.
|
|
Discussion of Findings: See sentinel report dated August 2005 and December 2001 for a discussion of the positive Simian Virus 5 (SV5) finding. |
| Feb 08 | C
| N
| V-160 M: All evaluations were negative for evidence of pathogens.
| Guinea pigs were also tested for mouse adenovirus-2. No fecal flotation test was performed.
|
Nov 07
|
|
| V-150 A: All evaluations were negative for evidence of pathogens.
| Guinea pigs were also tested for mouse adenovirus-2. No fecal flotation test was performed.
|
| Aug 07 |
|
|
| No
testing performed on guinea pigs. Only breeding colonies of
animals tested at this time, and no breeding guinea pigs were
maintained during this quarter.
|
May 07
|
|
|
| No testing performed on guinea pigs. There was no ongoing housing of guinea pigs at the time of testing.
|
Feb 07
|
|
|
| No
testing performed on guinea pigs. There was no ongoing housing of guinea pigs at the time of testing.
|
| Nov 06 | C
| N
| V-160 H: All evaluations were negative for evidence of pathogens.
| No fecal floatation conducted.
|
| Aug 06 |
|
|
| No
testing performed on guinea pigs. Only breeding colonies of
animals were tested at this time and no breeding guinea pigs were
maintained during this quarter.
|
| May 06 | C
| N
| V-160 H: Positive for Simian Virus 5 (SV5).
| Negative for all other tests. No fecal floatation conducted.
|
| Discussion of Findings:
See sentinel report dated August 2005 and December 2001 for a discussion of the positive Simian Virus 5 (SV5) finding.
|
| Feb 06 | C | N | Positive for Simian Virus 5 (SV5). | Negative for all other tests. |
| | Discussion of Findings:
See sentinel reports dated August 2005 and December 2001 for a discussion of the positive Simian Virus 5 (SV5) finding.
|
| Nov 05 |
|
|
| No guinea pigs were housed at this time.
|
Aug 05
| C | N | V-160 H: Positive for Simian Virus 5 (SV5) & Mouse Adenovirus-strain K87 (M.Ad-K87). | Negative for all other tests. |
| |
Discussion of Findings:
The
three animals that were evaluated were housed in the CMU for 2, 13, and
22 days, respectively. All three animals were positive for
M.Ad-K87 and SV5, strongly suggesting that exposure to the viruses
occurred prior to delivery to the CMU.
As reported in June 2004,
the positive results for M.Ad-K87 carry some uncertainty. It is
not clear if a positive result is indicative of a serologic response to
the actual M.Ad-K87 virus, which occurs in mice, or if it is a related
guinea pig adenovirus. Adenovirus infection in guinea pigs has
been associated with sporadic bronchopneumonia, seromucoid nasal
discharge, and sudden death with or without clinical signs. In
the past five years that the CMU has been housing guinea pigs, no
animals have shown clinical signs of pneumonia. As reported in
December 2001, the finding of serologoic evidence for Simian Virus 5
(SV5) in guinea pigs is not uncommon. One vendor has reported
that seropositive guinea pigs do not show clinical or pathological
signs of disease, and there has been no evidence of transmission of the
virus from guinea pigs to rats or mice. It has been suggested
that the positive serologic results are not due to SV5 antibodies but
rather due to seroconversion to a related human parainfluenze virus to
which guinea pigs are exposed.
|
May 05
|
|
|
| No guinea pigs were housed at this time.
|
| Feb 05 | C | N | Positive for Simian Virus 5 (SV5). | Negative for all other tests. |
| | Discussion of Findings:
See Discussion of Findings dated December 2001 for an explanation of the positive SV-5 finding in guinea pigs. |
| Nov 04 | C | N | Positive for Simian Virus 5 (SV5). | Negative for all other tests. |
| | Discussion of Findings:
See Discussion of Findings dated December 2001 for an explanation of the positive SV-5 finding in guinea pigs. |
| Aug 04 | C | N | Positive for Mouse Adenovirus-strain K87 (M.Ad-K87) and Simian Virus 5 (SV5). | Negative for all other tests. |
| | Discussion of Findings:
See Discussion of Findings dated December 2001 for an explanation of
the positive SV-5 finding in guinea pigs. See Discussion of Findings
dated May/June 2004 for an explanation of the positive M.Ad-87 finding. |
| May - June 04 | C | N | Positive for Mouse Adenovirus-strain K87 (M.Ad-K87 and Simian Virus 5 (SV5). | Negative for all other tests. |
| | Discussion of Findings:
Guinea pigs were found to be serologically positive for Mouse
Adenovirus-strain K87 (M.Ad-K87) and Simian Virus 5 (SV5). Because
guinea pigs are housed in the CMU for only short periods of time
(generally less than three weeks) before testing, we believe that the
results are indicative of infection prior to arrival in the CMU. We
plan to conduct arrival testing of the animals to confirm their
serologic status at that time.
See Discussion of Findings dated December 2001 for an explanation of the SV-5 finding.
Based upon a consultation with the Director of Laboratory Animal
Diagnostic Services at our testing laboratory, the positive results for
M.Ad-K87 carry some uncertainty. It is not clear if a positive result
is indicative of a serologic response to the actual M.Ad-K87 virus,
which occurs in mice, or if it is a related guinea pig adenovirus.
Adenovirus infection in guinea pigs has been associated with sporadic
bronchopneumonia, seromucoid nasal discharge, and sudden death with or
without clinical signs. In the past four years that the CMU has been
housing guinea pigs, no animals have shown clinical signs of pneumonia.
However, we had occasional spontaneous deaths of near term pregnant
guinea pigs attributed to ketoacidosis. |
| Feb 04 | No guinea pigs were housed at this time. |
| Oct - Dec 03 | No guinea pigs were housed at this time. |
| Aug - Sept 03 | No guinea pigs were housed at this time. |
| May - June 03 | No guinea pigs were housed at this time. |
| Feb 03 | No guinea pigs were housed at this time. |
| Nov 02 | No guinea pigs were housed at this time. |
| Aug 02 | No guinea pigs were housed at this time. |
| May - June 02 | No guinea pigs were housed at this time. |
| Feb - Mar 02 | No guinea pigs were housed at this time. |
| Dec 01 | C | N | Positive for Simian Virus 5 (SV5). | Negative for all other tests. |
| | Discussion of Findings:
The finding of serologic evidence for Simian Virus 5 (SV5) in guinea
pigs is not uncommon. SV5 was originally isolated from monkey kidney
cell cultures and has not been isolated from guinea pigs. After
extensive evaluation, one vendor reported that seropositive guinea pigs
do not show clinical or pathological signs of disease, and there has
been no evidence of transmission of the virus from guinea pigs to rats
or mice. It has been suggested that the positive serologic results are
not due to SV5 antibodies but rather due to seroconversion to a related
human parainfluenza virus to which guinea pigs are exposed. |
